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Efectul finasteridei (Propecia) asupra nivelului de DHT din tegumentul scalpului si ser

 

 

Finasteride 1mg (Propecia), este dovedit a fi cel mai eficient tratament nonchirurgical in tratarea alopeciei androgenetice la barbati.

Alopecia androgenetica este forma transmisa genetic de pierdere a podoabei capilare, dependenta de DHT (dihidrotestosteron). DHT este produs in organismul uman ca rezultat al interactiunii hormonului masculin testosteron cu enzima 5-alfa-reductaza. Finasteride functioneaza pe principiul inhibarii enzimei 5-alfa-reductazei de tip 2, implicit reducand nivelul seric de DHT si incetinind sau chiar oprind caderea parului. Deasemeni influenteaza pozitiv refacerea capilara si ingrosarea firelor subtiate prematur. Finasteride nu influenteaza inhibitia 5-alfareductazei de tip 1. Studiul efectuat de catre University of Oklahoma Health Sciences in 1999 a cautat sa determine efectul finasteridei la nivelul tegumentului scalpului precum si nivelele de androgeni serici

Metoda:

Barbati diagnosticati cu alopecie androgenetica, se biopsiaza inainte si dupa, tegumentul scalpului in vederea analizei nivelului de DHT sub influenta a 0.01, 0.05, 0.2, 1, sau 5 mg finasterida zilnic administrate pe perioada a 42 de zile. Comparatia s-a facut cu un grup placebo.

 

 

 

 

 

 

 

Rezultat:

In grupul placebo, nivelele DHT din tegumentul scalpului si respectiv ser, s-au redus cu 0,001 pana la13% . Tabelul evidentiaza efectele finasteridei in doze cuprinse intre 0,01 si 5 mg asupra nivelelor de DHT din tegumentul scalpului si respectiv ser.

 

 

Concluzii:

In acest studiu se arata ca dozele mici de finasterida de 0,2 mg per zi pot scadea dramatic nivelele serice si de la nivelul scalpului al DHT.

Nota:

Cele mai bune rezultate se vad abia dupa un tratament constiincios de cel putin un an de zile. Asocierea finasteridei ca tratament nonchirurgical cu implantul de par la persoanele ce sufera de alopecie androgenetica garanteaza un rezultat de succes.

In clinica Hair Implant Institute, recomandam utilizarea atat a finasteridei cat si a minoxidilului 5% in tratamentul post inteventiei de transplant de par.

Ne documentam in fiecare zi atat pentru cel mai bun tratament cat si pentru cea mai buna tehnica de implant de par pentru a mentine standarde de calitate superioare pentru pacientii nostri.

Vitamina D si cresterea parului

Vitamina D si cresterea parului

Vitamin D may be crucial in natural hair restoration.

35 milioane oameni din SUA prezinta semne de pierderea a parului tipic masculin. Wall Street Journalreported in urma unor studii din întreaga lume, indică faptul că "vitamina soarelui" are un efect pozitiv asupra receptorilor legati direct de cresterea parului.

Diverse studii sunt în curs de desfășurare pentru a demonstra capacitatea vitaminei D de a regenera parul prin activarea receptorilor corespunzători. Desi prea multa vitamina D poate avea efecte secundare nocive, dr. Hausler sugereaza ca pentru unele persoane care obțin întreaga doză zilnică recomandată de vitamina D, din alimente, cum ar fi peștele gras sau expunerea la soare, în general, poate îmbunătăți atat starea de sanatate cat si regenerarea capilara.

Au existat unele rapoarte cu privire la efectul vitaminei D asupra receptorilor de crestere a parului. Iată câteva informații despre unul dintre cele mai recente studii privind vitamina D și efectul acesteia asupra cresterii parului. Aoi et. Al. la Departamentul de Chirurgie Plastica de la Universitatea din Tokyo, a facut un studiu privind celulele papila dermica (CPD), care reprezintă una dintre cele două celule stem responsabile pentru creșterea părului uman (Aoi N, 2012).

Studiile anterioare au aratat ca Wnt de semnalizare este implicat în inițierea regenerarii folicului de par din celule stem. Stim de asemenea ca vitamina D3 (1α ,25-dihidroxivitamina D 3) sau VD3, care este forma activă a vitaminei D este implicată în faza de transformare a factorilor de creștere TGF, care este unul din factorii de creștere importanti în procesul de vindecare a rănilor și de creștere a părului.

Studiul acestui grup sugerează că vitamina D3 poate fi esențială în promovarea diferentierii celulelor papila dermica sau foliculilor pilosi din respectivele celulele stem. Rezultatul acestui studiu sugereaza ca vitamina D3 poate avea un rol major în tratamentul de regenerare a părului în viitor.

 

Bibliografie
Aoi N, I. K. (2012, Aug). 1α,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells: therapeutic potential for hair regeneration.

Alimentatie corecta pentru evitarea caderii parului

Dieta parului sanatos

„Mănâncă bine”, nu este suficient pentru a ingera toate ingredientele necesare pentru cresterea sanatoasa a parului. De fapt, cresterea parului este în mare măsură dependenta de o varietate de factori diferiți, dintre care multi sunt în afara controlului nostru. Factorul genetic individual, de exemplu, joacă un rol important în rata de creștere, grosimea, și densitatea firelor de păr. Cu toate acestea, studiile dovedesc o corelație pozitivă între anumite alimente si cresterea parului sanatos. Urmatoarele alimente și grupuri de produse alimentare au fost selectate nu doar pentru modul în care acestea pot avea un impact pozitiv in cresterea parului, dar si pentru modul în care ne ajuta sa aratam si sa ne simtim mai bine.

Alimentele naturale pentru un par sanatos:

1. Pestele (somon): Considerat de nutritionisti ca "cea mai buna" sursă de proteine, somonul are un profil nutritional, care este greu de învins. Omage-3 acizi grași, vitamine B-12, și fierul, face ca acest pește sa constituie o necesitate pentru persoanele fizice care doresc să adauge calitate la aportul de nutrienti zilnic
2. Fasole, năut, lint: rinichi, fasole neagra, naut, linte, soia si nuci, toate sunt exemple bune de leguminoase, care au un profil nutritional sanatos, ce poate imbunatati in mod semnificativ aspectul parului tau. Profilul nutritional include o cantitate substanțială de proteine, fier, zinc, biotina, fiecare dintre acestea reprezentand blocuri de construcție fundamentale pentru dezvoltarea sănătoasă a celulelor.

3. Nuci, migdale, caju: nuci, nuci braziliene, migdale, caju și sunt printre cele mai simple produse alimentare sănătoase și disponibile. Mai mult decât atât, aceste elemente populare alimentare sunt adesea disponibile în pachete unice de servire, ceea ce le face un ideal on the go.

4. Pui: pui este o sursa importanta de proteine ​​slabe, o componentă esențială a unei diete sanatoase, care a fost, de asemenea, legată de dezvoltarea unui par puternic si sanatos. Carnea de pui poat fi preparata în moduri nesănătoase, cu toate acestea, ca o regulă generală, aruncați mereu pielea si depozitele de grasime din pui, care este pregătit in modul rotisor. Pane și pui prăjit este, de asemenea, de evitat. În schimb, optati pentru pui la gratar, la cuptor, sau fript, care este preparat folosind extra virgin ulei de măsline, condimente, sare, și piper. Acest lucru va oferi o sumă substanțială de proteine ​​slabe, fără cantități nesănătoase de sodiu și grăsimi.

5. Ouă: Ouale sunt un aliment extrem de important in asigurarea sanatatii, deoarece acesta contine cantitati mari de proteine tip ​​cazeină, un tip special de "eliberare lenta", proteina care este cea mai raspandita in produsele lactate. Mai mult decât atât, galbenusul de ou este bogat în acizi grași omega, asemanator cu somonul.

 

Respectati un regim alimentar corect si veti evita mai tarziu un implant de par.

Cauzele de cadere a parului la femei

The causes of hair loss in women may differ from those in men due to a number of factors, most significant of which is biology.  One of the biggest biological differences between men and women are hormones.  Hormones like testosterone, estrogen, and thyroid, to name only a few, largely dictate the outward appearance of both males and females.  This includes height, weight, and of course, hair.  Other causes of hair loss in women include genetics, nutrient deficiencies, and general health of the skin (in particular, the scalp).  This article has been created to help women identify the 6 most common causes of hair lossincluding thinning, shedding, and balding.

Top 6 Causes of Hair Loss in Women

1. Unhealthy Scalp

It comes as no surprise that certain scalp conditions may be causal factors for hair loss.  The scalp is the foundation from which healthy hair grows, and growth may be inhibited when the foundation is compromised.  Specifically, the following skin conditions may lead to hair loss in women:

  • Seborrheic dermatitis:  This condition makes may agitate the skin of the scalp, face, and torso.  When affecting the scalp, most individuals know this condition by the name dandruff.
  • Psoriasis: An autoimmune disease, psoriasis appears in the form of scaly red and white patches on the upper most layer of skin.
  • Dermatophytosis: Known by the common name ringworm, dermatophytosis is caused by a fungal infection and appears as a light red circular mark on the skin.

2. Thyroid Disorder

Thyroid disorders are relatively common among American adults, affecting a reported 5 percent of the population.  Thyroid disorders come in one of two varieties:  Hypothyroidism and hyperthyroidism.  Both hypo- and hyperthyroidism may contribute to hair loss in women.  In the case of the former, the body under-produces the thyroid hormone and individuals may notice weight gain, persistent feelings of fatigue, and a general inability to concentrate.  Hyperthyroidism, on the other hand, is marked by an over-production of thyroid hormone that may cause other side effects like rapid weight loss, muscle atrophy, and irritability.

3. Telogen Effluvium

Another common cause of hair loss in women is telogen effluvium.  This disorder is characterized by unnatural thinning or shedding of the hair and is most commonly triggered by periods of immense or abrupt body stress.  Women who are pregnant, experiencing extreme weight loss, or feeling persistent mental/emotional stress may develop this scalp condition in which hair spends an abnormally short amount of time in the growing portion of the hair growth cycle.  This causes hair to enter the telogen phase (shedding phase) more quickly than is normal, increasing the rate at which hair is expelled from the scalp.

4. Androgenetic alopecia

The American Academy of Dermatology has named androgenetic alopecia as the most common cause of hair loss among both men and women.  Androgenetic alopecia is hereditary; the “gene for hair loss” may be passed down from parent to child.  Contrary to popular hair loss myths, androgenetic alopecia may be inherited from either the mother’s or father’s side of the family.

5. Alopecia Areata

Alopecia areata affects an estimated 4-5 million Americans, making this condition a very common reason for hair loss among women.  Though the precise cause of alopecia areata is not known, women who suffer with unhealthy amounts of stress or general illness are most susceptible to developing the condition.

6. Anemia

Anemia is caused be an iron deficiency in the blood.  This is marked by a low level of red blood cells and may be the result of a diet that is significantly lacking in iron rich foods like egg yolks, dark green vegetables, lentils, and artichokes, among others.  Anemia is also characterized by extreme fatigue and pale skin, as a low blood cell count renders the blood unable to transport adequate amounts of oxygen.

Un implant bine facut nu trebuie sa fie depistabil

 

When performed by an experienced physician, a hair transplant surgery can produce life long results that are so natural that even hair stylists cannot detect them. Choosing the best hair restoration procedure and physician is critical to your hair restoration success.

How Hair Grows

The portion of the hair that we can see is called the shaft. Each shaft of hair protrudes from its follicle, which is a tube-like pouch just below the surface of the skin. The hair is attached to the base of the follicle by the hair root, which is where the hair actually grows and where it is nourished by blood capillaries. Like the rest of the body, hairs are made of cells. As new cells form at its root, the hair is gradually pushed further and further out of the follicle. The cells at the base of each hair are close to the blood capillaries, and are living.
 
As they get pushed further away from the base of the follicle they no longer have any nourishment, and so they die. As they die, they are transformed into a hard protein called keratin. So, each hair we see above the skin is dead protein. It is the follicle, which lies deep in the skin, that is essential in growing hair. Also, the thickness of each hair depends on the size of the follicle from which it is growing.
 
Hair growth is not a continuous process: it has several stages.
 

ANAGEN PHASE

The first phase is the growing stage. Hair grows at about 1 cm each month, and this phase can last between 2 and 5 years.
 

CATAGEN PHASE

As this phase begins the bulb detaches from the blood supply and the hair shaft is pushed up.
 

THE TELOGEN PHASE

This is followed by a resting stage, during which there is no growth. This phase lasts about 5 months. At the end of the resting phase, the hair is shed, and the follicle starts to grow a new one. At any moment, about 90% of the hair follicles of the scalp are growing hairs in the first phase; only about 10% are in the resting phase. If a follicle is destroyed for any reason, no new hair will grow from it.
 

How Baldness Occurs

If any of the stages of hair growth are disrupted, the individual may become bald. For example, if follicles shut down (meaning that they stay in the resting phase, and then shed the hair) instead of growing new hairs, there will be less hair on the head. Another reason might be interference with the formation of new hair cells at the root during the growing phase. If follicles have been destroyed (i.e., a burn, loss of layered skin or trauma), there will be baldness in that area. An individual can also look bald if the hairs are growing but are so fragile that they break just as they emerge from the follicle.
 
Recently, scientists at Columbia University in New York announced the discovery of a gene that appears to be the 'master switch' for hair growth. They found the gene after comparing the genes of hairless mice belonging to a mutant breed, and comparing the genes of 11 members of a family who had lost all their hair. This discovery is a step towards understanding how the hair follicle works and how baldness happens, and may lead to effective treatments becoming available in the future.
 

Psychology of Hair Loss, Prevention and Re-growth

Hair forms a vital element of an individual's physical appearance. Changes in the hair, including its loss, can have correspondingly profound effects on interpersonal reactions and on self image. Studies that have specifically addressed the psychosocial impact of hair loss in men have shown that men with visible hair loss are perceived as older, weaker, and less physically attractive than their non-balding counterparts. Not surprisingly, such adverse social stereotyping of individuals with hair loss has a considerable impact on the self image, and therefore on the quality of life, of men with AGA. Studies confirm that the negative self-perception of hair loss by others is reflected in the psychological responses of balding men to their own condition. Using standard psychological tests, men with AGA report experiencing distress about their hair loss, feeling less physically attractive, and having greater body image dissatisfaction than their non-balding peers.
 
Given that many men are strongly motivated to seek help with their AGA, the treatment objectives may variously include the prevention of further hair loss, the maintenance of existing hair, the re-growth and retention of lost hair, or any combination of the three. In most cases, however, prevention and maintenance are the most realistic therapeutic options. In this context, it must be recognized that there is frequently a disparity between what the physician assumes are the patient's needs or requirements, and what the patient actually expects. Although there is a lack of rigorous scientific studies of men's attitudes towards re-growth of their lost hair as compared to the prevention of further hair loss, some indications are available in the literature. For example, in a study in which men with AGA completed the Hair Loss Effects Questionnaire (HLEQ), a high proportion gave responses that were directed towards a future rather than a present state: 93% worried about how much hair they would lose, 87% reported trying to estimate if they were losing more hair, and 8o% tried to imagine how they would look with more hair loss. Cash has also reported that balding men who anticipated more hair loss in the future experienced significantly greater negative events and cognitive preoccupation, and were also less satisfied with their hair and overall appearance than men who anticipated minimal future hair loss.
 
Some anecdotal evidence, based on market research among 2200 men with at least some degree of hair loss, strongly supports the importance of prevention rather than re-growth to the patient. Thus, when asked directly whether they were more concerned about the amount of hair they currently had (i.e. re-growth) or the rate at which they were losing it (i.e. prevention), most respondents (61%) were equally concerned about the two; of those expressing a greater concern for one or the other, two-thirds were more concerned with prevention and one-third with re-growth Although the ideal for most of the men involved in this research would clearly be a hair treatment that produced both re-growth and prevention, slightly more respondents thought that prevention (43%) rather than re-growth (34%) was essential in a hair loss treatment.
 

Therefore, it seems that many men are more anxious to prevent further hair loss in the future than they are to re-grow the hair they have already lost. Nonetheless, physicians may incorrectly believe that the patient will only be satisfied with overt re-growth, when in fact he would be content with retaining his remaining hair. This is an important point because secondary prevention, that is the prevention of further loss, is currently a more realistic treatment goal for the physician to offer. This is demonstrated by the drug treatments that have been or are now available

Testimoniale

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Cornel Prisacaru, Manager proiect

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Cristian Stoica, Psiholog